Carcinoma of unknown primary with a lung cancer profile in mediastinal and/or hilar lymph nodes: EGFR-mutant cases and a literature review of actionable drivers.

Abstract excerpt

We report two cases of carcinoma of unknown primary (CUP) with a lung cancer profile harboring epidermal growth factor receptor (EGFR) mutations. Case 1 was node-limited and achieved a durable partial response for at least 15 months with osimertinib. Case 2 harbored an EGFR exon 20 insertion and showed disease progression despite therapy. While responses to first- and second-generation EGFR tyrosine kinase...

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