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Article

A case of synchronous multiple primary lung cancers each harboring an EGFR mutation or an ALK fusion gene alone that responded to osimertinib with chemotherapy.

Respiratory investigation - 1 Mar 2026

Fukui Doppo, Morinaga Daisuke, Sakakibara-Konishi Jun, Yoshida Yukiko, Kashima Masahiro, Ito Shotaro, Furuta Megumi, Takashima Yuta, Tanei Zenichi, Konno Satoshi

Abstract excerpt

A comprehensive pathological evaluation is useful for diagnosing synchronous multiple primary lung cancer (sMPLC). However, a consensus regarding treatment for sMPLC with different driver mutations is lacking. We present a case of sMPLC harboring an epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) fusion gene. For the advanced EGFR-positive tumor, osimertinib plus chemotherapy...

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Identifiers

PMID: 41564844
DOI: 10.1016/j.resinv.2026.101375

Genes

ALK
EGFR

Provenance

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