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Article

Diagnosis and management of metastatic neoplasms with unknown primary.

Seminars in diagnostic pathology - 1 May 2018

Bochtler Tilmann, Löffler Harald, Krämer Alwin

Abstract excerpt

In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. The...

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Identifiers

PMID: 29203116
DOI: 10.1053/j.semdp.2017.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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