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Improved deconvolution of sequenced based mixtures by extending EuroForMix.

Forensic science international. Genetics - 1 Jun 2026

Bleka Ø, González-Bao J, de la Puente M, Gill P

Abstract excerpt

We present an extension of the EuroForMix model to improve genotype prediction for unknown contributors in Massively Parallel Sequencing (MPS) mixture data by incorporating marker amplification efficiency (MAE) parameters. The proposed two-step procedure first estimates MAE directly from the tested mixture profile and then treats these estimates as fixed inputs to the extended EuroForMix model, allowing the...

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PMID: 41797075
DOI: 10.1016/j.fsigen.2026.103479

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