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SMART-MHmix: A probabilistic model for microhaplotype-based forensic DNA mixture analysis.

Forensic science international. Genetics - 1 Jun 2026

Ji Xianchao, Feng Yaosen, Chi Lianjiang, Fu Mincong, Kang Kelai, Zhang Chi, Chen Jianchao, Wu Lan, Wang Le, Chen Hua

Abstract excerpt

The interpretation of complex DNA mixtures remains a persistent challenge in forensic genetics. Although probabilistic genotyping systems for capillary electrophoresis (CE)-based short tandem repeats (STRs) represent significant progress, their applicability is constrained by the inherent limitations of CE platform when analyzing highly complex mixtures. Microhaplotypes (MHs) are multi-allelic markers compatible...

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PMID: 42030864
DOI: 10.1016/j.fsigen.2026.103509

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