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Article

Genetically supported causality between alcohol dependence, immune cells and opioids tolerance: A two-sample Mendelian randomization study.

Progress in neuro-psychopharmacology & biological psychiatry - 2 Apr 2026

Liu Xu, Shen Dan, Zhao Zhili, Zhao Jiping, Ma Wenke, Song Na, Yang Jun, Wang Haijun

Abstract excerpt

BACKGROUND: Previous studies indicate a link between alcohol consumption, immune cells, and opioid tolerance, but causality is unclear. We use two-sample Mendelian randomization to explore this causal relationship and the impact of alcohol dependence and immune cells on opioid tolerance. METHODS: Mendelian randomization was used to analyze the causal association between alcohol dependence, immune cells, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41796722
DOI: 10.1016/j.pnpbp.2026.111662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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