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Revisiting the promise and pitfalls of mitochondrial replacement therapies.

Human reproduction (Oxford, England) - 1 Apr 2026

Costa-Borges Nuno, Wells Dagan

Abstract excerpt

Mitochondrial replacement therapies (MRTs) have been proposed as a means of avoiding the transmission of pathogenic mitochondrial DNA (mtDNA) mutations from mother to child. While clinical cases using this groundbreaking strategy have now been reported for the two principal MRT methods-pronuclear transfer and maternal spindle transfer-recent data continues to raise questions about the reliability of these...

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PMID: 41795216
DOI: 10.1093/humrep/deag020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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