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Prognostic factors and outcome measures after BRAF-directed targeted therapy of unresectable metastatic BRAFV600E colorectal cancer: a study cohort-level analysis.

Investigational new drugs - 1 Apr 2026

Colloca Giuseppe A, Venturino Antonella

Abstract excerpt

BRAFV600E mutation in metastatic colorectal cancer (mCRC) is associated with a poor prognosis. BRAFV600E inhibitors (BRAFi) plus EGFR inhibitors + / - MEK inhibitors regimens prolonged overall survival (OS), but prognosis remains heterogeneous and intermediate endpoints' reliability after BRAFi-based regimens has been poorly evaluated. The purpose of the study is to investigate the relationship of baseline...

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Identifiers

PMID: 41793630
DOI: 10.1007/s10637-026-01607-1

Genes

EGFR
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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