Article
BRAF Mutations Are Associated with Poor Survival Outcomes in Advanced-stage Mismatch Repair-deficient/Microsatellite High Colorectal Cancer.
The oncologist - 11 Mar 2022
Tan Elaine, Whiting Junmin, Xie Hao, Imanirad Iman, Carballido Estrella, Felder Seth, Frakes Jessica, Mo Quanxing, Walko Christine, Permuth Jennifer B, Sommerer Katelyn, Kim Richard, Anaya Daniel A, Fleming Jason B, Sahin Ibrahim Halil
Abstract excerpt
BACKGROUND: Mismatch repair-deficient (MMR-D)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) is a unique disease entity with growing interest given the rise of young-onset CRC. Given its heterogeneous behavior and potential for highly effective treatment outcomes, we...
Topics
- Child, Preschool
- Colonic Neoplasms
- Colorectal Neoplasms
- DNA Mismatch Repair
- Humans
- Microsatellite Instability
- Microsatellite Repeats
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)
- Retrospective Studies