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Article

Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Majeed Abdul, Tahir Ul Qamar Muhammad, Maryam Arooma, Mirza Muhammad Usman, Alhussain Laila, Al Otaibi Seham Obaid, Almatroudi Ahmad, Allemailem Khaled S, Alrumaihi Faris, Aloliqi Abdulaziz A, Alshehri Faez Falah

Abstract excerpt

Despite advanced diagnosis and detection technologies, prostate cancer (PCa) is the most prevalent neoplasms in males. Dysregulation of the androgen receptor (AR) is centrally involved in the tumorigenesis of PCa cells. Acquisition of drug resistance due to modifications in AR leads to therapeutic failure and relapse in PCa. An overhaul of comprehensive catalogues of cancer-causing mutations and their juxta...

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Source

Identifiers

PMID: 37144757
DOI: 10.1080/07391102.2023.2208203

Genes

AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer.PMID 37144757Read ↗

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