Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational analysis of androgen receptor (AR) variants to decipher the relationship between protein stability and related-diseases.

Scientific reports - 21 Jul 2020

Chen Fangfang, Chen Xiaoqing, Jiang Fan, Leng Feng, Liu Wei, Gui Yaoting, Yu Jing

Abstract excerpt

Although more than 1,000 androgen receptor (AR) mutations have been identified and these mutants are pathologically important, few theoretical studies have investigated the role of AR protein folding stability in disease and its relationship with the phenotype of the patients. Here, we extracted AR variant data from four databases: ARDB, HGMD, Cosmic, and 1,000 genome. 905 androgen insensitivity syndrome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgen-Insensitivity Syndrome
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Guanidine

Share to Prostatic Neoplasms

Share to Protein Conformation

Share to Protein Stability

Share to Receptors, Androgen

Source

Open in PubMed Open full text

Identifiers

PMID: 32694570
DOI: 10.1038/s41598-020-68731-7
PMCID: PMC7374729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of androgen receptor (AR) variants to decipher the relationship between protein stability and related-diseases.PMID 32694570Read ↗

Characterization of a novel androgen receptor gene variant identified in an Iranian family with complete androgen insensitivity syndrome (CAIS): a molecular dynamics simulation study.Semantic proximity Read ↗

Weak linkage in androgen receptor: identification of mutation-prone points.Semantic proximity Read ↗

Pathophysiology of androgen insensitivity syndromes: molecular and structural approaches of natural and engineered androgen receptor mutations at amino acid 743.Semantic proximity Read ↗

Complete androgen insensitivity syndrome caused by a novel mutation in the androgen receptor gene and its mechanism.Semantic proximity Read ↗

Molecular biology of androgen insensitivity.Semantic proximity Read ↗

Clinical, cytogenetic and molecular analysis of androgen insensitivity syndromes from south Indian cohort and detection and in-silico characterization of androgen receptor gene mutations.Semantic proximity Read ↗

A hemizygous mutation in the androgen receptor gene causes different phenotypes of androgen insensitivity syndrome in two siblings by disrupting the nuclear translocation.Semantic proximity Read ↗

In-vitro characterization of androgen receptor mutations associated with complete androgen insensitivity syndrome reveals distinct functional deficits.Semantic proximity Read ↗

The androgen receptor gene mutations database (ARDB): 2004 update.Semantic proximity Read ↗

Evolution of the androgen receptor: structure-function implications.Semantic proximity Read ↗

A functional analysis of disease-associated mutations in the androgen receptor gene.Semantic proximity Read ↗

A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.