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Article

Analysis of the binding modes of the first- and second-generation antiandrogens with respect to F876L mutation.

Chemical biology & drug design - 1 Jul 2021

Shao Guangfeng, Bao Jingxiao, Pan Xiaolin, He Xiao, Qi Yifei, Zhang John Z H

Abstract excerpt

Androgen receptor (AR) is an important target for the treatment of prostate cancer, and mutations in the AR have an important impact on the resistance of existing drugs. In this work, we performed molecular dynamics simulations of the existing marketed antiandrogens flutamide, nilutamide, bicalutamide, enzalutamide, apalutamide, darolutamide, and its main metabolite ORM15341 in complex with the wild-type and...

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PMID: 33905591
DOI: 10.1111/cbdd.13848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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