Article
Effects of counter ion protonation on the ultrafast excited-state dynamics in archaerhodopsin-3.
Biophysical journal - 19 May 2026
Herasymenko Krystyna, Walisinghe Danushka, Konno Masae, Ledentu Vincent, Huix-Rotllant Miquel, Yang Xuchun, Ferré Nicolas, Inoue Keiichi, Olivucci Massimo, Haacke Stefan
Abstract excerpt
Archaerhodopsin-3 (AR-3) and its mutants have attracted large attention for applications in optogenetics since they display a voltage-sensitive, near-infrared fluorescence. Recent quantum chemistry modeling of the electrostatic interactions between the protein environment and the protonated Schiff base retinal gave a detailed insight about the origin of a mutation-induced excited-state barrier, which hinders the...
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