Article
Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors.
Iranian journal of allergy, asthma, and immunology - 6 Jun 2021
Azizi Seyed Ghader, Samiee Shahram, Shaiegan Mojgan, Zadsar Maryam
Abstract excerpt
Human platelet antigens (HPAs) are glycoproteins on the platelet surface that a single nucleotide mutation in the coding region gene could lead to the variation of different HPA polymorphisms. These antigens have shown variation among different races and may trigger immune responses during blood transfusion and pregnancy. Genotyping of HPAs is useful for managing these reactions and establishing a platelet...
Topics
- Antigens, Human Platelet
- Blood Donors
- Blood Grouping and Crossmatching
- Blood Platelets
- Blood Transfusion
- DNA Primers
- Gene Frequency
- Genotype
- Histocompatibility
- Humans