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Article

Association of OBPIIa genetic variants with prodromal Parkinsonian phenotypes and dopaminergic biomarkers in the PPMI cohort.

Journal of the neurological sciences - 15 May 2026

Jiang Chunyan, Kong Zhen, Zhou Yuting, He Qiqing, Dou Kaixin, Hou Binghui, Li Yaqing, Xie Anmu

Abstract excerpt

BACKGROUND: Odorant-binding protein IIa (OBPIIa) gene variants are linked to Parkinson's disease (PD)-related olfactory loss, but their role in clinical subtypes and mechanisms remains unclear. This study examined associations with clinical scales, neuroimaging, and cerebrospinal fluid (CSF) biomarkers. METHODS: Data from the Parkinson's Progression Markers Initiative (PPMI) cohort were analyzed. Multinomial...

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PMID: 41791219
DOI: 10.1016/j.jns.2026.125845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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