Article
Assessment of clonality of multisegmental main duct intraductal papillary mucinous neoplasms of the pancreas based on GNAS mutation analysis.
Surgery - 1 Feb 2015
Tamura Koji, Ohtsuka Takao, Matsunaga Taketo, Kimura Hideyo, Watanabe Yusuke, Ideno Noboru, Aso Teppei, Miyazaki Tetsuyuki, Ohuchida Kenoki, Takahata Shunichi, Ito Tetsuhide, Ushijima Yasuhiro, Oda Yoshinao, Mizumoto Kazuhiro, Tanaka Masao
Abstract excerpt
BACKGROUND: Main duct intraductal papillary mucinous neoplasms (MD-IPMNs) may occur in 1 or multiple segments of the pancreatic duct. Unlike multifocal branch duct (BD)-IPMNs, the clonality of multisegmental MD-IPMNs remains unclear. GNAS mutations are common and specific for IPMNs, and mutational assessment might be useful to determine the clonality of IPMNs as well as to detect high-risk IPMN with distinct...
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