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Article

Microglandular adenosis, triple negative breast carcinoma and DNA repair defects.

Journal of clinical pathology - 17 Apr 2026

Bedell Mariel, da Silva Edaise M, Selenica Pier, Gazzo Andrea M, Blanco Heredia Juan, Basili Thais, Elishaev Esther, Harinath Lakshmi, Diego Emilia, Tageja Nishant, Weigelt Britta, Reis-Filho Jorge S, Bhargava Rohit

Abstract excerpt

AIMS: A subset of microglandular adenosis (MGA) displays protein expression and molecular genetic alterations similar to those of synchronous triple-negative breast carcinoma (TNBC), supporting the hypothesis that MGA is a non-obligate precursor lesion to a subset of breast carcinomas. Here, we further explore this association in the context of genomic instability. METHODS: We use whole-genome sequencing to...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Germ-Line Mutation

Share to Loss of Heterozygosity

Share to MutS Homolog 2 Protein

Share to Triple Negative Breast Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41775529
DOI: 10.1136/jcp-2025-210512
PMCID: PMC13078391

Genes

MGA
MSH2
TP53
BRCA2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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