Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beyond mobility: A prospective study on diet and metabolism in hereditary spastic paraplegia.

Metabolic brain disease - 3 Mar 2026

Erhardt Christina, Spatz Imke T, Herrmann Hans J, Kohl Zacharias, Zopf Yurdagül, Gassner Heiko, Winkler Jürgen, Regensburger Martin

Abstract excerpt

Metabolism plays an important role in neurodegenerative diseases. Hereditary spastic paraplegias (HSP) are a heterogeneous group of rare genetic neurodegenerative disorders, commonly characterized by the clinical syndrome of progressive lower limb spasticity and mobility loss. Obesity has been linked to distinct genotypes, but the role of metabolism and nutrition in HSP remains unclear.We aimed to To evaluate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATPases Associated with Diverse Cellular Activities
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Metalloendopeptidases

Share to Nutritional Status

Share to Pilot Projects

Share to Spastic Paraplegia, Hereditary

Source

Open in PubMed Open full text

Identifiers

PMID: 41774218
DOI: 10.1007/s11011-026-01815-x
PMCID: PMC12956933

Genes

SPG11
SPG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beyond mobility: A prospective study on diet and metabolism in hereditary spastic paraplegia.PMID 41774218Read ↗

Hereditary spastic paraplegia type 11 (SPG11) is associated with obesity and hypothalamic damage.Semantic proximity Read ↗

Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia.Semantic proximity Read ↗

Hereditary spastic paraplegia: Novel insights into the pathogenesis and managementSemantic proximity Read ↗

Lipids in the Physiopathology of Hereditary Spastic ParaplegiasSemantic proximity Read ↗

Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial.Semantic proximity Read ↗

Nutritional, Lipid Metabolic and Body Composition Features of Children with Spinal Muscular AtrophySemantic proximity Read ↗

Non-motor symptoms are relevant and possibly treatable in hereditary spastic paraplegia type 4 (SPG4)Semantic proximity Read ↗

Genes and exercise intolerance: insights from McArdle disease.Semantic proximity Read ↗

Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5.Semantic proximity Read ↗

Impairment of brain and muscle energy metabolism detected by magnetic resonance spectroscopy in hereditary spastic paraparesis type 28 patients with DDHD1 mutations.Semantic proximity Read ↗

Genetic variation in human muscle strength--opportunities for therapeutic interventions?Semantic proximity Read ↗

Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.