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Article

Hereditary spastic paraplegia type 11 (SPG11) is associated with obesity and hypothalamic damage.

Journal of the neurological sciences - 15 Sept 2020

Cardozo-Hernández Ana Luisa de Carvalho, Rezende Thiago Junqueira Ribeiro, França Marcondes Cavalcante

Abstract excerpt

SPG11 mutations lead to heterogeneous neurological phenotypes, but metabolic abnormalities have not yet been explored in this disease. In this study, we investigate whether SPG11 pathogenic variants might affect metabolic regulation, leading to weight changes and if this could relate to hypothalamic damage. In this cross-sectional case-control study, we selected a group of individuals with confirmed SPG11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32593884
DOI: 10.1016/j.jns.2020.116982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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