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Article

Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia.

Nutrients - 13 Nov 2022

Regensburger Martin, Krumm Laura, Schmidt Manuel Alexander, Schmid Andreas, Spatz Imke Tabea, Marterstock Dominique Cornelius, Kopp Christoph, Kohl Zacharias, Doerfler Arnd, Karrasch Thomas, Winner Beate, Winkler Jürgen

Abstract excerpt

BACKGROUND: Pathogenic variants in SPG11 cause the most common autosomal recessive complicated hereditary spastic paraplegia. Besides the prototypical combination of spastic paraplegia with a thin corpus callosum, obesity has increasingly been reported in this multisystem neurodegenerative disease. However, a detailed analysis of the metabolic state is lacking. METHODS: In order to characterize metabolic...

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PMID: 36432490
DOI: 10.3390/nu14224803
PMCID: PMC9693816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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