Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pseudomonas aeruginosa tRNA nucleotidyltransferase Cca controls resistance and tolerance to aminoglycoside antibiotics by regulating the MexXY multidrug efflux pump.

Antimicrobial agents and chemotherapy - 1 Apr 2026

Shen Chenyu, Wang Lepeng, Zhang Yu, Zhang Linyan, Cheng Zhihui, Wu Weihui, Ha Un-Hwan, Jin Shouguang, Jin Yongxin

Abstract excerpt

Pseudomonas aeruginosa displays high resistance to a wide range of antibiotics, greatly impeding clinical treatment. MexXY efflux pump plays an important role in bacterial resistance and tolerance to aminoglycoside antibiotics. tRNA nucleotidyltransferase (Cca, CCA-adding enzyme) is a universal polymerase responsible for the synthesis and repair of the 3'-terminal CCA sequence of tRNA. In this study, we found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Microbial Sensitivity Tests

Share to Nucleotidyltransferases

Share to Pseudomonas aeruginosa

Share to RNA Nucleotidyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 41773979
DOI: 10.1128/aac.01653-25
PMCID: PMC13041342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pseudomonas aeruginosa tRNA nucleotidyltransferase Cca controls resistance and tolerance to aminoglycoside antibiotics by regulating the MexXY multidrug efflux pump.PMID 41773979Read ↗

MexXY multidrug efflux system of Pseudomonas aeruginosaSemantic proximity Read ↗

SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa.Semantic proximity Read ↗

tRNA queuosine modification is involved in biofilm formation and virulence in bacteriaSemantic proximity Read ↗

Mutations in Gene fusA1 as a Novel Mechanism of Aminoglycoside Resistance in Clinical Strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Regulation of antibiotic-resistance by non-coding RNAs in bacteria.Semantic proximity Read ↗

Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux systemSemantic proximity Read ↗

TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa.Semantic proximity Read ↗

Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly CorrelatedSemantic proximity Read ↗

Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ.Semantic proximity Read ↗

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Novel Plasmid-Mediated 16S rRNA Methylase, RmtC, Found in a Proteus mirabilis Isolate Demonstrating Extraordinary High-Level Resistance against Various AminoglycosidesSemantic proximity Read ↗

Recycling of Peptidyl-tRNAs by Peptidyl-tRNA Hydrolase Counteracts Azithromycin-Mediated Effects on Pseudomonas aeruginosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.