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Article

Heterogeneous effect of saxagliptin on glucose fluctuation and β-cell function in T1DM: a multicentre, randomised trial.

Nutrition & diabetes - 2 Mar 2026

Shi Yun, Shen Min, Gu Yong, Chen Yang, Xu Kuanfeng, Hu Ji, Fang Chen, Guo Heming, Xu Ning, Wang Guofeng, Lu Weiping, Tao Sha, Zhao Songqing, Fang Chengxia, Ma Jianhua, Yan Rengna, Sun Rui, Qian Li, Wu Chenguang, Jiang Hui, Yang Tao

Abstract excerpt

BACKGROUND AND AIMS: We aimed to explore whether saxagliptin, a dipeptidyl peptidase-IV inhibitor, could ameliorate glucose fluctuations and maintain β-cell function in T1DM. METHODS AND RESULTS: A multicentre, open-label, randomised trial was performed, including 184 T1DM patients from six medical centres. These patients received insulin with or without saxagliptin at 5 mg per day for 24 weeks. The primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41771842
DOI: 10.1038/s41387-026-00411-3
PMCID: PMC12987927

Genes

GLP1R
PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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