Article
Genetic and epigenetic markers in colorectal cancer screening: recent advances.
Expert review of molecular diagnostics - 1 Jul 2017
Singh Manish Pratap, Rai Sandhya, Suyal Shradha, Singh Sunil Kumar, Singh Nand Kumar, Agarwal Akash, Srivastava Sameer
Abstract excerpt
INTRODUCTION: Colorectal cancer (CRC) is a heterogenous disease which develops from benign intraepithelial lesions known as adenomas to malignant carcinomas. Acquired alterations in Wnt signaling, TGFβ, MAPK pathway genes and clonal propagation of altered cells are responsible for this transformation. Detection of adenomas or early stage cancer in asymptomatic patients and better prognostic and predictive markers...
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