Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.

doi:10.1038/s10038-026-01464-z

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Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.

Journal of human genetics - 1 Jul 2026

Kimura Kaori, Kuwata Takeshi, Hiraoka Yumie, Matsukawa Manami, Tomozawa Chikako, Aitani Miki, Komura Yu, Miki Izumi, Wakabayashi Masashi, Furui Yosuke, Kondo Hiroki, Saigoh Kazumasa, Yamamoto Yasuko, Akagi Kiwamu, Narimatsu Hiroto, Yokono Megumu, Amano Shinsuke, Muto Kaori, Nagami Fuji, Kato Kazuto, Yamashita Riu, Imoto Issei, Kosugi Shinji, Hirata Makoto, Yoshino Takayuki, Nakamura Yoshiaki

Abstract excerpt

Multigene panel testing (MGPT) is increasingly used for diagnosing hereditary cancers; however, its application in cascade testing remains limited, and the psychological impact on unaffected relatives is not well understood. This multicenter study in Japan recruited 123 first-degree relatives without a personal history of cancer to evaluate psychological responses before (T0) and two weeks after (T1) MGPT result...

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PMID: 41765989
DOI: 10.1038/s10038-026-01464-z
PMCID: PMC13303072

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