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Article

Factors affecting the implementation of cascade testing of patients with BRCA1 or BRCA2 pathogenic germline variants in Japan.

Journal of genetic counseling - 1 Jun 2025

Kiyozumi Yoshimi, Nishimura Seiichiro, Kado Nobuhiro, Higashigawa Satomi, Horiuchi Yasue, Ishihara Eiko, Harada Rina, Matsubayashi Hiroyuki

Abstract excerpt

In clinical management for hereditary cancer patients, risk assessment is needed not only for patients but also for their blood relatives. In people with Hereditary Breast and Ovarian Cancer syndrome (HBOC), benefits are demonstrated by identifying relatives with BRCA1 and BRCA2 pathogenic germline variants (PGV) and implementing clinical surveillance and risk-reduction surgeries for the at-risk organs. To date,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40361302
DOI: 10.1002/jgc4.70055

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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