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Article

Cascade testing for hereditary cancer: comprehensive multigene panels identify unexpected actionable findings in relatives.

Journal of the National Cancer Institute - 8 Feb 2024

Heald Brandie, Pirzadeh-Miller Sara, Ellsworth Rachel E, Nielsen Sarah M, Russell Emily M, Beitsch Peter, Esplin Edward D, Nussbaum Robert L, Pineda-Alvarez Daniel E, Kurian Allison W, Hampel Heather

Abstract excerpt

Current guidelines recommend single variant testing in relatives of patients with known pathogenic or likely pathogenic germline variants in cancer predisposition genes. This approach may preclude the use of risk-reducing strategies in family members who have pathogenic or likely pathogenic germline variants in other cancer predisposition genes. Cascade testing using multigene panels was performed in 3696...

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Identifiers

PMID: 37756683
DOI: 10.1093/jnci/djad203
PMCID: PMC10852611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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