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Drosophila melanogaster miPEP8 Regulates Cell Size Through its Interaction With ref(2)P/p62.

Molecular & cellular proteomics : MCP - 1 Apr 2026

Duboé Carine, Guillon Clémence, Jariais Nathanael, Boutet Jessica, Pichereaux Carole, Chaoui Karima, Näser Emmanuelle, Combier Jean-Philippe, Brun Christine, Martineau Yvan, Burlet-Schiltz Odile, Plaza Serge, Fabre Bertrand

Abstract excerpt

MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster, named miPEP8, which is involved in the regulation of wing size. However, mechanisms at play are unknown. In the present study, we take advantage of the Drosophila cell line Schneider 2 (S2) to further investigate miPEP8 function at the...

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PMID: 41765287
DOI: 10.1016/j.mcpro.2026.101544
PMCID: PMC13053990

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