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Article

The role of Ire1 in Drosophila eye pigmentation revealed by an RNase dead allele.

Developmental biology - 1 Oct 2021

Mitra Sahana, Ryoo Hyung Don

Abstract excerpt

Ire1 is an endoplasmic reticulum (ER) transmembrane RNase that cleaves substrate mRNAs to help cells adapt to ER stress. Because there are cell types with physiological ER stress, loss of Ire1 results in metabolic and developmental defects in diverse organisms. In Drosophila, Ire1 mutants show developmental defects at early larval stages and in pupal eye photoreceptor differentiation. These Drosophila studies...

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Share to Endoplasmic Reticulum Stress
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Photoreceptor Cells, Invertebrate

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Identifiers

PMID: 34265355
DOI: 10.1016/j.ydbio.2021.07.008
PMCID: PMC8364510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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