High-throughput functional screening for autophagy-related genes and identification of<i>TM9SF1</i>as an autophagosome-inducing gene

Abstract excerpt

Autophagy, a tightly regulated process responsible for the bulk degradation of most long-lived proteins and some organelles, is associated with several forms of human diseases including cancer, neurodegenerative disease and cardiomyopathies. However, the molecular machinery involved in autophagy in mammalian cells remains poorly understood. Here, we describe a high-throughput, cell-based functional screening...

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