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Article

Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis

21 Feb 2020

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Skin barrier defects contribute to disease initiation and development; however, underlying mechanisms remain elusive. OBJECTIVE: To understand the underlying cause of barrier defect, we investigated aberrant expression of specific microRNAs (miRNAs) in AD. Delineating the molecular mechanism of dysregulated miRNA network, we focused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32088305
DOI: 10.1016/j.jaci.2020.02.007

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