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Different Intensities of Physical Activity Substituted for Sedentary Time and Risk of Type 2 Diabetes: Integration of Genetics and Wearable Data.

Mayo Clinic proceedings - 1 Mar 2026

Shi Qiaoxin, Jang Haeyoon, Collings Paul James, Wang Mengyao, Chen Ziyuan, Luo Shan, Au Yeung Shiu Lun, Wan Yuk Fai Eric, Griffin Simon J, Sharp Stephen J, Day Felix, Ong Ken K, Brage Soren, Kim Youngwon

Abstract excerpt

OBJECTIVE: To investigate whether substituting different intensities of physical activity (PA) for sedentary time (ST) can benefit the prevention of type 2 diabetes (T2D) across varying levels of T2D genetic susceptibility. PARTICIPANTS AND METHODS: We included 73,272 White British participants from the UK Biobank without prevalent T2D. Wrist-worn accelerometry was used to derive sleep, ST, light PA, and...

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PMID: 41055629
DOI: 10.1016/j.mayocp.2025.04.033

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