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Development and application of a tetra-ARMS PCR assay for detecting indel polymorphisms in the bovine PRNP gene.

Analytical methods : advancing methods and applications - 12 Mar 2026

Xu Ye, Yang Siyu, Ding Siling, Xu Ting, Ge Jian, Xiao Weiming, Zhu Like, Guan Feng

Abstract excerpt

Insertion/deletion (indel) polymorphisms in the promoter region (23 bp) and intron 1 (12 bp) of the bovine PRNP gene influence gene expression and susceptibility to bovine spongiform encephalopathy (BSE). Conventional detection strategies dependent on DNA sequencing are cumbersome and costly. A tetra-primer amplification refractory mutation system PCR (tetra-ARMS PCR) assay was developed which can enable...

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PMID: 41757693
DOI: 10.1039/d5ay02047f

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PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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