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Article

Single Isothermal Assay for Multi-Site Mutation Detection of Rifampicin Resistance in Mycobacterium tuberculosis.

Pathogens (Basel, Switzerland) - 8 Feb 2026

Nandu Nidhi, Miller Michael, Lu Zhi-Xiang

Abstract excerpt

Antimicrobial drug resistance is an escalating global health burden, often driven by multiple genetic changes within key resistance-associated genes. Achieving multiplex capability of mutation detection while maintaining simplicity and affordability is critical, particularly in point-of-care and resource-limited settings. Here, we introduce a strategy for multi-site mutation detection using single isothermal...

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Identifiers

PMID: 41754439
DOI: 10.3390/pathogens15020187
PMCID: PMC12943657

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