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Article

Exploratory Analysis of Candidate Gene Variants in Developmental Dysplasia of the Hip: Evidence for the Role of GDF5 rs143384.

Genes - 25 Jan 2026

Harsanyi Stefan, Neuschlova Lucia, Milosovicova Lubica, Zamborsky Radoslav, Pastorakova Andrea, Danisovic Lubos

Abstract excerpt

BACKGROUND: Developmental dysplasia of the hip (DDH) is a common orthopedic disorder characterized by abnormal development of the hip joint, which can lead to pain, instability, and early-onset osteoarthritis if left untreated. Its etiology is multifactorial, involving both genetic and environmental factors. METHODS: This study investigated the association between selected single-nucleotide polymorphisms (SNPs)...

Topics

Humans
Growth Differentiation Factor 5
Polymorphism, Single Nucleotide
Female
Male
Developmental Dysplasia of the Hip
Genetic Predisposition to Disease
DNA Copy Number Variations
Case-Control Studies
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41751511
DOI: 10.3390/genes17020129
PMCID: PMC12940396

Genes

GDF5
COL1A1
CX3CR1
MMP24
TGFB1
COL2A1
DKK1
FZD4
LRP5
NDP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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