Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relevance of polymorphisms in TLR2/4 genes and their association with plasma cytokines for schizophrenia.

Genes and immunity - 1 Apr 2026

Patlola Saahithh Redddi, Laighneach Aodán, Morris Derek W, Hallahan Brian, McDonald Colm, Kelly John P, Donohoe Gary, McKernan Declan P

Abstract excerpt

Schizophrenia is associated with altered levels of plasma cytokines. Toll-like receptors (TLRs) can be responsible for cytokine synthesis. It remains unclear whether genetic changes in TLRs, e.g. single-nucleotide polymorphisms (SNPs), account for altered levels. Here, we investigate the relationship between SNPs in TLR2 and TLR4 genes, cytokine levels, and cognition. This study included 281 participants (190...

Topics

Join the communities discussing this publication.

Case-Control Studies
Cognition
Cytokines
Interleukin-6
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Toll-Like Receptor 2

Toll-Like Receptor 4

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 41748904
DOI: 10.1038/s41435-026-00383-5
PMCID: PMC13086572

Genes

TLR2
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relevance of polymorphisms in TLR2/4 genes and their association with plasma cytokines for schizophrenia.PMID 41748904Read ↗

Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia.Semantic proximity Read ↗

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.Semantic proximity Read ↗

Toll-Like Receptor 4 Gene Polymorphisms and Susceptibility to Schizophrenia: A Case-Control Study.Semantic proximity Read ↗

Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.Semantic proximity Read ↗

Association between TLR2 polymorphisms (- 196-174 Ins/Del, R677W, R753Q, and P631H) and schizophrenia in a Tunisian population.Semantic proximity Read ↗

Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia.Semantic proximity Read ↗

Genetic Predisposition of TLR 1 and TLR 6 Polymorphisms to Schizophrenia Onset and Prediction of Treatment Response.Semantic proximity Read ↗

Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype.Semantic proximity Read ↗

The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophreniaSemantic proximity Read ↗

Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Meta-Analysis of Cytokine and Chemokine Genes in Schizophrenia.Semantic proximity Read ↗

TLR2 genetic diversity and the risk of SchizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.