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Article

Genotype-Guided P2Y12-Inhibitor De-Escalation Strategy in Acute Coronary Syndrome: Observational Evidence From the POPular-GUIDE PCI.

Circulation. Cardiovascular interventions - 1 May 2026

van den Broek Wout W A, Azzahhafi Jaouad, van de Pol Qiu Ying F, Chan Pin Yin Dean R P P, van der Sangen Niels M R, Sivanesan Shabiga, Peper J, Harmsze Ankie M, Walhout Ronald J, Tjon Joe Gin Melvyn, Breet Nicoline J, Langerveld Jorina, Appelman Yolande, van Schaik Ron H N, Henriques José P S, Kikkert Wouter J, Ten Berg Jurriën M

Abstract excerpt

BACKGROUND: A genotype-guided de-escalation strategy-switching from a potent P2Y12 inhibitor to clopidogrel-may reduce bleeding risk in patients with acute coronary syndrome. This analysis evaluated the safety and effectiveness of routine genetic testing to guide antiplatelet therapy in clinical practice. METHODS: In this investigator-initiated, prospective, multicenter implementation study, patients received...

Topics

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Acute Coronary Syndrome
Clinical Decision-Making
Clopidogrel
Drug Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Percutaneous Coronary Intervention

Pharmacogenomic Testing

Purinergic P2Y Receptor Antagonists

Receptors, Purinergic P2Y12

Source

Identifiers

PMID: 41744086
DOI: 10.1161/CIRCINTERVENTIONS.125.016084

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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