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Article

Genotype-Guided vs Conventional Oral P2Y12 Inhibitors in Acute Coronary Syndrome: A Combined Analysis of TAILOR-PCI and POPular Genetics.

JACC. Cardiovascular interventions - 9 Feb 2026

Galli Mattia, Pereira Naveen L, Lennon Ryan J, van den Broek Wout W A, Claassens Daniel M F, Bergmeijer Thomas O, Rosenberg Yves, Fazzini Luca, Deneer Vera H M, Murad M Hassan, Farkouh Michael E, Rihal Charanjit, Ten Berg Jurrien, Angiolillo Dominick J

Abstract excerpt

BACKGROUND: Genotype-guided P2Y12 inhibitor selection may improve outcomes in acute coronary syndrome (ACS) or percutaneous coronary interventions (PCI) patients. OBJECTIVES: This study sought to assess the impact of guided therapy escalation or de-escalation vs conventional therapy. METHODS: Randomized controlled trials comparing guided therapy using CYP2C19 genetic testing vs conventional therapy among patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41672687
DOI: 10.1016/j.jcin.2025.11.029

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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