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Optimizing P2Y12 Inhibitor Therapy in Post-PCI Patients Through Genotype-Guided Strategies: A Systematic Review and Meta-Analysis.

Cardiovascular drugs and therapy - 1 Jun 2026

Hamza Mohammad, Karamat Mubashar, Harmouch Khaled M, Alamzaib Sardar M, Jabeen Sidra, Basit Jawad, Bhanushali Karan, Ved Rohan, Rashdi Amna, Almani Muhammad Usman, Syed Moinuddin, Sattar Yasar, Alraies M Chadi

Abstract excerpt

BACKGROUND: Clopidogrel non-responder is a common dilemma in the management of post-percutaneous coronary intervention (PCI) management. Clopidogrel is metabolized by CYP2C19. The genetic variations in CYP2C19 can affect the efficacy and bioavailability of the drug that can be checked via genotype testing of the gene. This study evaluates the impact of genotype versus conventional guided P2Y12 inhibitor therapy...

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Source

Identifiers

PMID: 40788330
DOI: 10.1007/s10557-025-07747-5

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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