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Article

CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings.

Journal of the American Heart Association - 15 Feb 2022

Beitelshees Amber L, Thomas Cameron D, Empey Philip E, Stouffer George A, Angiolillo Dominick J, Franchi Francesco, Tuteja Sony, Limdi Nita A, Lee James C, Duarte Julio D, Kreutz Rolf P, Skaar Todd C, Coons James C, Giri Jay, McDonough Caitrin W, Rowland Rachel, Stevenson James M, Thai Thuy, Vesely Mark R, Wellen Jacob T, Johnson Julie A, Winterstein Almut G, Cavallari Larisa H, Lee Craig R

Abstract excerpt

Background Studies have demonstrated increased risk of major atherothrombotic events in CYP2C19 loss-of-function (LOF) variant carriers versus non-carriers treated with clopidogrel after percutaneous coronary intervention (PCI). We sought to evaluate real-world outcomes with the clinical implementation of CYP2C19-guided antiplatelet therapy after PCI. Methods and Results Data from 9 medical centers where...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35156424
DOI: 10.1161/JAHA.121.024159
PMCID: PMC9245803

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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