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Digital PCR Assay Utilizing In‐Droplet Methylation‐Sensitive Digestion for Estimation of Fetal cfDNA From Plasma

16 Mar 2025

Abstract excerpt

OBJECTIVE: Recent guidelines suggest that non-invasive prenatal screening (NIPS) should be offered to all patients with singleton and twin pregnancies. Accurate determination of fetal fraction in cell-free DNA (cfDNA) is vital for reliable NIPS outcomes. We propose a methylation-based approach using droplet digital PCR (ddPCR) and methylation-sensitive restriction enzyme (MSRE) digestion for fetal fraction...

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PMID: 40090860
DOI: 10.1002/pd.6774

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