Article
Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking.
Scientific reports - 3 Feb 2016
Georgiadis Panagiotis, Hebels Dennie G, Valavanis Ioannis, Liampa Irene, Bergdahl Ingvar A, Johansson Anders, Palli Domenico, Chadeau-Hyam Marc, Chatziioannou Aristotelis, Jennen Danyel G J, Krauskopf Julian, Jetten Marlon J, Kleinjans Jos C S, Vineis Paolo, Kyrtopoulos Soterios A
Abstract excerpt
The utility of blood-based omic profiles for linking environmental exposures to their potential health effects was evaluated in 649 individuals, drawn from the general population, in relation to tobacco smoking, an exposure with well-characterised health effects. Using disease connectivity analysis, we found that the combination of smoking-modified, genome-wide gene (including miRNA) expression and DNA...
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