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Article

Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma

21 Aug 2019

Abstract excerpt

). Further, potential functional DNA methylation-gene expression-overall survival pathways were evaluated by causal mediation analysis. The effect of DNA methylation level on LUAD survival was significantly mediated through gene expression level. By adding DNA methylation and gene expression biomarkers to a model of only clinical data, the AUCs of the trans-omics model improved by 18.3% (to 87.2%) and 16.4% (to...

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PMID: 31434796
DOI: 10.18632/aging.102189

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