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Article

Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

You Jason C, Bender Alex C, Berezuk Courtney, Noriega-Makarskyy Daisy T, Baena Ana, Munera Diana, Pardilla-Delgado Enmanuelle, Ramirez-Gomez Liliana, Aguillon David, Giudicessi Averi, Martinez Jairo E, Cronin-Golomb Alice, Lam Alice D, Quiroz Yakeel T

Abstract excerpt

INTRODUCTION: Accelerated long-term forgetting (ALF) may represent one of the earliest cognitive changes in Alzheimer's disease (AD). However, whether ALF emerges in the preclinical stage of autosomal-dominant AD (ADAD) is unclear, and its underlying mechanisms are poorly understood. METHODS: We assessed ALF via long-term memory testing, sleep physiology via overnight electroencephalography, and AD neuropathology...

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Identifiers

PMID: 41724664
DOI: 10.1002/alz.71235
PMCID: PMC12927940

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PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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