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Article

The prognostic impact of KRAS, TP53, STK11 and KEAP1 mutations and their influence on the NLR in NSCLC patients treated with immunotherapy.

Cancer treatment and research communications - 1 Jan 2023

Proulx-Rocray Francis, Routy Bertrand, Nassabein Rami, Belkaid Wiam, Tran-Thanh Danh, Malo Julie, Tonneau Marion, Ouarzadi Omar El, Florescu Marie, Tehfe Mustapha, Blais Normand

Abstract excerpt

BACKGROUND: PD-L1 expression is used to predict NSCLC response to ICIs, but its performance is suboptimal. The impact of KRAS mutations in these patients is unclear. Studies evaluating co-mutations in TP53, STK11 and KEAP1 as well as the NLR showed that they may predict the benefit of ICIs. PATIENTS & METHODS: This is a retrospective study of patients with NSCLC treated with ICIs at the CHUM between July 2015 and...

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Carcinoma, Non-Small-Cell Lung
Immunotherapy
Kelch-Like ECH-Associated Protein 1
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-E2-Related Factor 2

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

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PMID: 37832364
DOI: 10.1016/j.ctarc.2023.100767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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