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rs6897932 (C>T) and rs987106 (A>T) variants in the IL7RA gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus.

Lupus - 1 Apr 2026

Sarpeleh Faezeh, Ehtesham Naeim, Mirjani Ruhollah, Mohammadi Yousef, Kenarangi Taiebe, Mosallaei Meysam, Ansari Narges

Abstract excerpt

ObjectiveThe dysfunction of interleukin-7 receptor alpha (IL-7Rα), which is encoded by the IL7RA gene, has been implicated in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the relationship between two specific single-nucleotide polymorphisms (SNPs) in the IL7RA gene-rs6897932 (C>T) and rs987106 (A>T)-and the risk of developing SLE.MethodsBlood samples were obtained from...

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PMID: 41721827
DOI: 10.1177/09612033261429135

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