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Article

Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts.

PloS one - 1 Jan 2026

Unten Yufu, Takafuji Kazuaki, Masukagami Yumiko, Shiiba Isshin, Horiuchi Keigo, Husnik Filip, Yanagi Shigeru, Tateishi Norifumi, Suzuki Toshihide

Abstract excerpt

Age-associated declines in skeletal muscle function are linked to cellular senescence and mitochondrial alterations, yet mitochondrial phenotypes in aged human myoblasts remain insufficiently characterized. Here, we examined primary skeletal muscle myoblasts from young and elderly donors to assess mitochondrial function, morphology, and mitochondria-endoplasmic reticulum (ER) contact sites (MERCS). Myoblasts from...

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Share to Cellular Senescence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potential, Mitochondrial

Share to Mitochondria, Muscle

Share to Myoblasts, Skeletal

Share to Oxidative Stress

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Identifiers

PMID: 41719251
DOI: 10.1371/journal.pone.0343604
PMCID: PMC12923047

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