Respiratory Chain Complex Disorganization Impairs Mitochondrial and Cellular Integrity: Phenotypic Variation in Cytochrome c Oxidase Deficiency.

doi:10.1016/j.ajpath.2016.09.003

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Article

Respiratory Chain Complex Disorganization Impairs Mitochondrial and Cellular Integrity: Phenotypic Variation in Cytochrome c Oxidase Deficiency.

The American journal of pathology - 1 Jan 2017

Hatakeyama Hideyuki, Goto Yu-Ichi

Abstract excerpt

The relationships between the molecular abnormalities in mitochondrial respiratory chain complexes and their negative contributions to mitochondrial and cellular functions have been proved to be essential for better understandings in mitochondrial medicine. Herein, we established the method to identify disease phenotypic differences among patients with muscle histopathological cytochrome c oxidase (COX)...

Topics

Cytochrome-c Oxidase Deficiency
Electron Transport Complex IV
Holoenzymes
Homeostasis
Humans
Mitochondria
Models, Biological
Muscle Development
Muscle, Skeletal
Mutation
Phenotype
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 27855277
DOI: 10.1016/j.ajpath.2016.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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