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Genomic Analysis of Doxycycline Resistance-Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum.

Emerging infectious diseases - 1 Feb 2026

Long George S, Neale Mackenzie, Braukmann Thomas, Tran Vanessa, Singh Nishant, Allen Vanessa, Morshed Muhammad, Minion Jessica, Van Caeseele Paul, Vallée Maud, Hatchette Todd, Patel Samir N, Tsang Raymond S W, Duvvuri Venkata R

Abstract excerpt

We inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance. Variants were detected in 9 non-Canada genomes. These findings establish a global genomic baseline for monitoring doxycycline resistance in syphilis.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41714842
DOI: 10.3201/eid3202.251060
PMCID: PMC12928234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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