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Utilization of Serum Metabolomics and Polygenic Risk Scores in a Novel Risk Stratification Tool for the Prediction of Incident Atrial Fibrillation.

Circulation. Arrhythmia and electrophysiology - 1 Mar 2026

Purkayastha Subhanik, Park Joseph, Beyer Sebastian E, Chandra Arun, Markowitz Steven M, Lerman Bruce B, Elemento Olivier, Krumsiek Jan, Lo James C, Cheung Jim W

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is associated with substantial morbidity and mortality. We sought to investigate the predictive value of serum metabolomics for 5-year incident AF in the context of clinical and polygenic risk score (PRS) stratification tools. METHODS: We studied a cohort of 240 628 patients UK Biobank participants with proton nuclear magnetic resonance spectroscopy measurements of 170 serum...

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PMID: 41711031
DOI: 10.1161/CIRCEP.125.013858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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