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Article

Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast.

EMBO reports - 1 Mar 2026

Tawfeeq Mohammed T, Konstantinidis Dimitrios, Rocha Iraizos Ana Lucia, Van Genechten Wouter, Vreys Jolien, Vermeersch Lieselotte, Voordeckers Karin, Van Dijck Patrick, Verstrepen Kevin J

Abstract excerpt

Gim3 is an evolutionarily conserved component of the prefoldin chaperone complex, involved in protein folding. We previously found that GIM3 genetically interacts with many de novo mutations in Saccharomyces cerevisiae. Removing GIM3 from mutagenized S. cerevisiae cells significantly affected the fitness effect of mutations. This indicates that Gim3 might change the evolutionary impact of de novo mutations by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41703071
DOI: 10.1038/s44319-026-00702-x
PMCID: PMC13022404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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